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Every wellness insider has their hidden shelf of must-haves—the lineup of powders, capsules, and tonics that’s as much a part of daily life as coffee in the morning. We’re talking about the ride-or-die formulas that move with us from suitcase to nightstand, from red-eye flights to post-holiday resets.
Over the years, we’ve tested just about everything in the wellness aisle—some promising, some overhyped, and a rare few that truly earn their keep. What we’ve landed on is a short list of supplements that never fail us: the ones that keep digestion happy, immunity humming, stress levels in check, and beauty rituals running strong.
Consider this your peek into our cupboard, carry-on, and desk drawer. These are the tried-and-true supplements that have stood the test of busy schedules, long flights, and countless wellness trends—and the ones we can’t imagine living without.
IM8 Daily Ultimate Essentials
We don’t say this lightly: IM8 Daily Ultimate Essentials is a wellness unicorn. We first tried it last year, and one of our editors swears it saved him while traveling through Bali—when jet lag and a bug hit, IM8 was the thing that helped him bounce back.
This all-in-one daily drink is the definition of comprehensive. Instead of juggling 16 bottles, it combines 92 nutrient-rich ingredients—think vitamins, minerals, antioxidants, greens, pre-pro-post-biotics, and clinical dosages of CoQ10 and MSM—into one delicious serving. Bonus: everything is third-party tested, so you know you’re getting exactly what the label promises. It’s convenience, potency, and peace of mind all in one glass, which is why it’s permanently stocked on our shelf. SHOP HERE
Agent Nateur holi (mane)
Collagen has been everywhere in the wellness world, but few formulas deliver like Agent Nateur’s holi (mane). It’s on nearly every editor’s “must-have” list for good reason: stronger nails, thicker hair, and skin that feels a little more glowy, all without any weird taste.
Developed with functional medicine pro Dr. Will Cole, this bestselling powder blends marine collagen with pearl powder, plus 30+ minerals, amino acids, and antioxidants. It’s not just about beauty—it also helps boost glutathione and superoxide dismutase, two key antioxidants for overall vitality. In other words, it’s not hype; it’s results. And yes, we keep a backup bag in the cupboard. SHOP HERE
Cymbiotika Liposomal Glutathione
If you’ve been following wellness trends, you know Cymbiotika is always a step ahead. Co-founder Chervin Jafarieh has a knack for spotting what’s next (he helped make Shilajit a thing in the U.S.), and their Liposomal Glutathione is a perfect example of that innovation.
Glutathione is known as the body’s “master antioxidant”—it detoxifies, protects cells, and supports immunity. Cymbiotika takes it up a notch with a liposomal delivery system that ensures higher absorption than standard supplements. The formula also includes PQQ for brain and mitochondrial health and just the right touch of B2 to round it out. Clean, powerful, and cleverly formulated, this one keeps us feeling energized and resilient, no matter how hectic life gets. SHOP HERE
Host Defense Turkey Tail
Our secret weapon when travel takes a toll? Host Defense Turkey Tail. This mushroom hero has saved us more than once when our immunity needed a nudge. It’s always stashed in our carry-on and in our office, ready to keep things balanced.
Turkey Tail is one of the most studied functional mushrooms, known for supporting gut health, feeding good bacteria, and helping the immune system do its job without overreacting. Host Defense backs this up with serious research, including NIH-funded studies that prove the benefits of both the mycelium and its fermented substrate. Translation: this isn’t just a mushroom trend; it’s legit, clinically-backed support. For us, it’s non-negotiable. SHOP HERE
Natural Vitality CALM® Raspberry-Lemon Powder
Last but never least: CALM. If you’ve been in the wellness world for a while, you’ve probably tried this iconic magnesium powder at least once. And for good reason since the 1980s, it’s been the go-to for stress relief and sleep support.
We love the raspberry-lemon flavor and the ritual of watching it fizz to life in warm water. The science is simple but effective: it turns into highly absorbable Ionic Magnesium Citrate, helping replenish your magnesium stores while easing stress. The travel sticks are a bonus, perfect for tossing in a bag for flights or late nights at the office. It’s soothing, effective, and honestly, kind of fun. SHOP HERE
